Administration of Vaccine Preservative Thimerosal Produces Impairment in Rat Liver

The present research was planned to analyze the toxic effects of thimerosal on rat liver. Mercury and mercury compounds are universally known toxicants for animals humans. Thimerosal is widely used in vaccines as a preservative which contains 49.6% mercury. Twenty-four adult male albino rats were distributed into four groups (n=6). first group considered control group. While, second, third fourth intoxicated with 0.5, 10 50 µg/kg (i.m.) respectively. After 30 days, slaughtered liver tissues. results experiment exposed that instigated significant (p<0.05) increase alanine transaminase (ALT), alkaline phosphatase (ALP) aminotransferase (AST) levels. Catalase (CAT), superoxide dismutase (SOD), peroxidase (POD) activities Glutathione (GSH) protein levels significantly reduced. Furthermore, increases Hydrogen peroxide (H2O2), thiobarbituric acid reactive substances (TBARS) level DNA damage observed. Histopathological study revealed severe damages, e.g. fatty alterations, deterioration lobular structure degeneration nuclei hepatic tissues treated rats. Results investigation induces hepatotoxicity at different